Police were called at approximately 3.55am on Saturday, 9 February to reports of a male seen in possession of a firearm in the vicinity of Lewisham Road, SE13.
The caller also raised concerns for the welfare of a woman at an address in Lewisham Road.
Officers, including armed officers, attended the scene and stopped a vehicle near to the junction with Blackheath Hill.
A police firearm was discharged.
One man, believed aged in his 20s, was taken to a south hospital suffering a gunshot injury. His condition is not life-threatening. He has been arrested.
A further six males have been arrested; five for false imprisonment and one for possession of an offensive weapon.
Enquiries into the circumstances remain ongoing.
Road closures remain in place around the scene, which is on the border of Greenwich and Lewisham boroughs.
The Directorate of Professional Standards and the Independent Office for Police Conduct have been informed.